SITAYES-M (Sitagliptin + Metformin)

MOA

1. Sitagliptin inhibits DPP-4
2. Increases incretin hormones
3. Enhances insulin release
4. Metformin reduces glucose production
5. Improves insulin sensitivity
6. Decreases intestinal glucose absorption
7. Controls blood glucose

Uses

1. Type 2 diabetes
2. Poor glycemic control
3. Combination therapy
4. Obese diabetics
5. Insulin resistance
6. Long-term diabetes control
7. Metabolic syndrome

Side Effects

1. Diarrhea
2. Nausea
3. Abdominal discomfort
4. Hypoglycemia (rare)
5. Headache
6. Dizziness
7. Vitamin B12 deficiency

Precautions

1. Take with meals
2. Monitor renal function
3. Avoid alcohol
4. Check B12 levels
5. Avoid in severe renal disease
6. Monitor sugar levels
7. Use under supervision

Tags: Sitagliptin + Metformin