KETOYES-30 Injection

Generic Name

Ketorolac Tromethamine Injection IP

Composition

Each ml contains:

• Ketorolac Tromethamine IP  
• Sterile aqueous vehicle q.s.

Product Description

KETOYES-30 contains Ketorolac Tromethamine, a potent non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe acute pain. It provides analgesic, anti-inflammatory, and antipyretic effects and is commonly used when oral administration is not feasible.

Mechanism of Action (MOA)

Ketorolac works by:

• Inhibiting Cyclooxygenase (COX-1 and COX-2) enzymes
• Reducing the synthesis of prostaglandins
• Decreasing pain, inflammation, and fever

This results in rapid pain relief without the use of opioid medications.

Indications / Uses

• Post-operative pain
• Orthopedic pain
• Musculoskeletal pain
• Acute trauma-related pain
• Renal colic
• Dental pain
• Cancer-related pain (adjunct therapy)
• Pain associated with fractures and injuries

Benefits

• Rapid onset of action
• Strong analgesic effect
• Opioid-sparing alternative
• Effective in acute moderate-to-severe pain
• Available for IM and IV administration

Dosage & Administration

Route:

• Intramuscular (IM)
• Intravenous (IV)

Dosage should be administered strictly under medical supervision.

Maximum treatment duration: Generally not more than 5 days.

Contraindications

Do not use in patients with:

• Hypersensitivity to Ketorolac or NSAIDs
• Active peptic ulcer disease
• Gastrointestinal bleeding
• Severe renal impairment
• History of aspirin-induced asthma
• Bleeding disorders
• During labor and delivery
• Concomitant use with other NSAIDs

Precautions

• Use cautiously in elderly patients
• Monitor renal function during therapy
• Avoid prolonged use
• Maintain adequate hydration
• Use with caution in cardiovascular disease
• Monitor for signs of GI bleeding

Possible Side Effects

Common

• Nausea
• Vomiting
• Headache
• Dizziness
• Abdominal pain
• Dyspepsia

Less Common

• Injection site pain
• Drowsiness
• Edema
• Increased blood pressure

Serious

• Gastrointestinal bleeding
• Peptic ulceration
• Renal failure
• Anaphylactic reactions
• Bronchospasm

Seek immediate medical attention if serious adverse effects occur.

Drug Interactions

• Aspirin
• Other NSAIDs
• Anticoagulants (Warfarin, Heparin)
• Corticosteroids
• ACE inhibitors
• Diuretics
• Lithium
• Methotrexate

Storage

• Store below 25°C.
• Protect from light.
• Do not freeze.
• Keep out of reach of children.