Ceftriaxone Injection I.P. 1 g

Brand Names: VDOCEF 1 g Injection

Composition

Each vial contains:

• Ceftriaxone Sodium I.P. equivalent to Ceftriaxone 1000 mg (1 g)

Model / Generic Name

Ceftriaxone Injection I.P. 1 g

Pharmacological Class

• Third Generation Cephalosporin Antibiotic

Mechanism of Action

Ceftriaxone inhibits bacterial cell wall synthesis, resulting in the death of susceptible bacteria. It is highly effective against a broad range of Gram-positive and Gram-negative organisms.

Indications / Uses

Used for the treatment of bacterial infections, including:

• Respiratory tract infections
• Pneumonia
• Urinary tract infections (UTI)
• Typhoid fever
• Septicemia (blood infections)
• Meningitis
• Gonorrhea
• Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• Surgical prophylaxis

Spectrum of Activity

Effective against:

• Escherichia coli
• Klebsiella species
• Proteus species
• Salmonella typhi
• Streptococcus pneumoniae
• Neisseria gonorrhoeae
• Haemophilus influenzae

Dosage and Administration

• Route: Intramuscular (IM) or Intravenous (IV)
• Typical adult dosage: 1–2 g once daily, depending on severity of infection
• Higher doses may be used in severe infections under medical supervision

Reconstitution

Reconstitute with:

• Sterile Water for Injection
• Lidocaine (for IM use only, as prescribed)

Common Side Effects

• Injection site pain
• Nausea
• Vomiting
• Diarrhea
• Skin rash
• Headache

Serious Adverse Effects

• Allergic reactions
• Severe diarrhea (Clostridioides difficile-associated)
• Elevated liver enzymes
• Blood count abnormalities

Contraindications

• Hypersensitivity to cephalosporins
• Severe allergy to penicillins (use with caution)
• Neonates receiving calcium-containing IV solutions

Precautions

• Use cautiously in patients with liver or kidney impairment
• Complete the full prescribed course
• Use only for bacterial infections

Use in Pregnancy and Lactation

Generally considered safe when used under medical supervision.

Storage

• Store below 25°C
• Protect from light and moisture
• Use immediately after reconstitution

Vial / Packaging

• 1 Glass Vial containing sterile powder for injection
• Single-dose vial
• May be supplied with Sterile Water for Injection depending on manufacturer

Unit of Sale

Per Vial

Tags: Ceftriaxone Injection I.P. 1 g