Kelamik-100

Amikacin Sulphate is a broad-spectrum aminoglycoside antibiotic used for severe bacterial infections.
It is effective mainly against Gram-negative organisms.
Administered via IM or IV route under medical supervision.
Commonly used in hospital settings.
Available in strengths like 100 mg and 250 mg.
Acts rapidly in bloodstream infections.
Reserved for serious infections to prevent resistance.

Mechanism of Action (MOA)

Amikacin binds to the 30S ribosomal subunit of bacteria.
It inhibits protein synthesis in bacterial cells.
Causes misreading of mRNA.
Leads to production of nonfunctional proteins.
Results in bacterial cell death (bactericidal action).
Highly effective against aerobic Gram-negative bacteria.
Resistant to many bacterial enzymes that inactivate other aminoglycosides.

Uses

Septicemia and bloodstream infections.
Respiratory tract infections like pneumonia.
Urinary tract infections (complicated cases).
Intra-abdominal infections.
Skin and soft tissue infections.
Bone and joint infections.
Post-surgical infections.

Side Effects

Nephrotoxicity (kidney damage).
Ototoxicity (hearing loss or tinnitus).
Injection site pain.
Dizziness or vertigo.
Allergic reactions (rare).
Nausea and vomiting.
Electrolyte imbalance.

Precautions

Monitor kidney function regularly.
Use cautiously in elderly patients.
Avoid in patients with hearing impairment.
Dose adjustment in renal impairment.
Avoid prolonged use.
Use in pregnancy only if necessary.
Ensure proper hydration.

Tags: Amikacin Sulphate