KEFUYES-CV 375 (Cefuroxime 250 mg + Clavulanic Acid 125 mg Tablets)

Uses 

1. Respiratory tract infections
2. Sinusitis
3. Urinary tract infections (UTI)
4. Skin and soft tissue infections
5. Tonsillitis and pharyngitis
6. Bronchitis
7. Dental infections

Side Effects 

1. Diarrhea
2. Nausea
3. Vomiting
4. Abdominal pain
5. Headache
6. Skin rash
7. Fungal superinfection (rare)

Precautions 

1. Check for cephalosporin/penicillin allergy
2. Use cautiously in liver disease
3. Monitor liver function
4. Complete full antibiotic course
5. Avoid unnecessary use (resistance risk)
6. Use in pregnancy only if prescribed
7. Adjust dose in renal impairment

Mechanism of Action (MOA) 

1. Cefuroxime inhibits bacterial cell wall synthesis
2. Binds to penicillin-binding proteins (PBPs)
3. Causes bacterial cell lysis (bactericidal)
4. Clavulanic acid is a β-lactamase inhibitor
5. Protects cefuroxime from enzyme degradation
6. Enhances antibacterial spectrum
7. Effective against resistant organisms